On Ions, Channels, Pumps, and Water – The mechanisms of cellular ion, water, and volume homeostasis, and their functional sequel
On July 5th, 2022, Alexey Andreevich Vereninov, a pioneer in the field of cellular electrochemistry, passed away at the age of 90. Vereninov was the Head of the Laboratory of Cell Physiology at the Institute of Cytology of the Russian Academy of Sciences from 1986 - 2019 and was leading the Physiology of Membrane Transport group until his death. The scientific community lost a giant, one of the last Mohicans of the early years of cellular electrophysiology.
Vereninov ́s work encompasses major achievements in the understanding of the electrophysiological behavior of excitable and non-excitable cells, and especially in the field of ion and water homeostasis. His theoretical and experimental studies focused on the nature, mechanisms, and dynamics of ion distribution between the intra- and extracellular space and the associated phenomena. These studies were crucial in understanding of cellular ion homeostasis, excitability, regulation of cell hydration and volume, cell proliferation, and programmed cell death. His work was characterized by experimental rigor, deep understanding of theory, and imagination.
This special issue includes original research articles and reviews centered around, related to, or influenced by the work of Alexey A. Vereninov. This includes but is not restricted to the concepts of pump-leak in ion distribution, Donnan equilibrium, ion channel and transporter structure and function, cellular excitability, cellular water balance and volume regulation, the role of ion transport in cell proliferation and programmed cell death, methods for cellular and subcellular ion measurements, and mathematical and computational modelling of ion transport.